US PATENT SUBCLASS 530 / 390.5
.~.~.~.~ Removing, dissociating, or preventing the formation of aggregated, denatured, fragmented, or polymerized immunoglobulin or antibody; or preventing or reducing complement fixation or binding; or reducing antigenicity; or removing, inactivating, or inhibiting contaminating plasma proteins (e.g., proteolytic enzymes, etc.)

Current as of: June, 1999
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530 /   HD   CHEMISTRY: NATURAL RESINS OR DERIVATIVES; PEPTIDES OR PROTEINS; LIGNINS OR REACTION PRODUCTS THEREOF

350  DF  PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES {14}
380  DF  .~ Blood proteins or globulins, e.g., proteoglycans, platelet factor 4, thyroglobulin, thyroxine, etc. {3}
386  DF  .~.~ Globulins {4}
387.1  DF  .~.~.~ Immunoglobulin, antibody, or fragment thereof, other than immunoglobulin antibody, or fragment thereof that is conjugated or absorbed {9}
390.5.~.~.~.~ Removing, dissociating, or preventing the formation of aggregated, denatured, fragmented, or polymerized immunoglobulin or antibody; or preventing or reducing complement fixation or binding; or reducing antigenicity; or removing, inactivating, or inhibiting contaminating plasma proteins (e.g., proteolytic enzymes, etc.)

DEFINITION

Classification: 530/390.5

Removing, dissociating or preventing the formation of aggregated, denatured, fragmented, or polymerized immunoglobulin or antibody; or preventing or reducing complement fixation or binding; or reducing antigenicity; or removing, inactivating, or inhibiting contaminating plasma proteins (e.g., proteolytic enzymes, etc.):

(under subclass 387.1) Subject matter involving a process of removing, dissociating, or preventing the formation of aggregated, denatured, fragmented, polymerized immunoglobulins or antibodies; or a process of preventing or reducing complement fixation or complement binding by an immunoglobulin preparation; or a process of reducing the antigenicity of an immunoglobulin preparation; or a process of removing, inactivating, or inhibiting plasma proteins, such as proteolytic enzymes, that contaminate an immunoglobulin preparation; or involving an immunoglobulin preparation prepared thereby.

(1) Note. This subclass provides for methods of removing plasma proteins that co-purify with immunoglobulins and for methods of removing immunoglobulin fragments or aggregates that create adverse effects, such as complement activation--i.e., "anticomplementary activity"--when an immunoglobulin preparation is administered intravenously.

SEE OR SEARCH THIS CLASS, SUBCLASS:

831, for immunoglobulins isolated via the Cohn fractionation method.