US PATENT SUBCLASS 530 / 350
PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES


Current as of: June, 1999
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530 /   HD   CHEMISTRY: NATURAL RESINS OR DERIVATIVES; PEPTIDES OR PROTEINS; LIGNINS OR REACTION PRODUCTS THEREOF

350PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES {14}
351  DF  .~> Lymphokines, e.g., interferons, interlukins, etc.
352  DF  .~> Phosphoproteins, e.g., phosvitin, vitellogenin, etc.
353  DF  .~> Scleroproteins, e.g., fibroin, elastin, silk, etc. {3}
358  DF  .~> Nucleoproteins, e.g., chromatin, chromosomal proteins, histones, protamines, salmine, etc.
359  DF  .~> Lipoproteins, e.g., egg yolk proteins, cylomicrons, etc.
360  DF  .~> Casein or caseinate {1}
362  DF  .~> Albumin {4}
370  DF  .~> Plant proteins, e.g., derived from legumes, algae or lichens, etc. {4}
380  DF  .~> Blood proteins or globulins, e.g., proteoglycans, platelet factor 4, thyroglobulin, thyroxine, etc. {3}
395  DF  .~> Glycoprotein, e.g., mucins proteoglycans, etc. {2}
399  DF  .~> Hormones, e.g., prolactin, thymosin, growth factors, etc.
400  DF  .~> Metal containing, e.g., chromoproteins, ferritin, ferredoxins, etc. {1}
402  DF  .~> Chemical modification or the reaction product thereof, e.g., covalent attachment or coupling, etc. {5}
412  DF  .~> Separation or purification {6}


DEFINITION

Classification: 530/350

PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES:

(under the class definition) Subject matter in which a polypeptide is composed of more than 100 amino acid residues or has a molecular weight of greater than 10,000.

(1) Note. This subclass will provide for proteins described only in terms of physical properties such as molecular weight, electrophoretic mobility, etc.

(2) Note. Structures. The primary structure of the shorter peptides has been included in the definitions. For the proteins the Merck Monograph will often provide citation to articles disclosing the structure. The structure of the larger peptides and proteins may be found on the on-line services by using the compound name, Chemical Abstracts Registry Number, or National Library of Medicine's MESH tree number in combination with the terms "sequence" or "structure".

(3) Note. Compositions. In general a protein containing composition will be provided for in a class providing for the function or utility of the composition, e.g., medicine, food, Class 252 utilities, etc.

A protein mixed with a preserving agent whose sole function is to prevent chemical or physical change is provided for with the peptide or protein.

A protein derived from a single source material such as a plant or animal extract, so long as it is identified as a protein is classified in this class (530) even if a Class 424 utility is disclosed or claimed. A plant or animal extract will be provided for in Class 424 if it is (1) a single source material and (2) is of undetermined chemical constitution i.e., is claimed in terms of isolation technique or physical properties. A recitation as broad as "protein" is enough to defeat placement in Class 424 on the basis of utility.

Class 424 will provide for an additive mixture containing a protein and other ingredients if the mixture has a Class 424 utility. (4) Note. CAS REGISTRY NUMBERS: Chemical Abstracts Service (CAS) Registry Numbers are unique identifiers assigned to chemical substances recorded in the CAS Chemical Registry System. The CAS Registry Number itself has no chemical significance; it is simply a machine-checkable number assigned to each substance as it enters the Registry System. CAS Registry Numbers appear in CA issues and in many computer-readable files. They also may be found in several primary journals, various handbooks, and in the National Library of Medicine's TOXLINE and CHEMLINE computer-based information-retrieval services. For more about the CAS Chemical Registry System or Registry Numbers consult the introduction to the CAS REGISTRY HANDBOOK-Number Section.

Medical Subject Headings:

Mesh Tree Numbers: Mesh numbers are identifiers applied the National Library of Medicine's indexers to articles in the medical and related literature. The subject headings are Index Medicus headings and are arranged in a hierarchical matter. The abstracts and indexing are available on-line through several data base suppliers.

Deleted Registry Numbers: The CAS Registry numbers found in the definitions of subclass 300 to 427 are the current registry numbers. However due to the long history and incomplete structural knowledge of peptide and protein chemistry there are usually several deleted registry numbers for each current registry number. The current registry number should be used to find the deleted numbers in the registry file and should always be included in the on-line search statement. For further information on search technique related to deleted registry numbers, see CAS ON-LINE NEWS, May/June 1984 page 5.

(5) Note. Synthetic Resin vs. Polypeptide. The conceptual difference between the subject matter of synthetic resins provided for in the 520 series and polypeptides (including

proteins) provided for in Class 530 is that the compounds of the 520 series have statistically distributed amino acid or blocks of amino acids in their molecules in a random sequence whereas 530 provides for molecules composed of a specific sequence of amino acids of defined identity and order (i.e., primary structure) having identity or close relation to a humerial or cellular polypeptide or having some humerial or cellular effect due to its ordered structure.

(7) Note. Classification of the more common amino acids:

Amino Acids

Classification

Amino Acids commonly found in peptides and proteins:

Alanine

562/575 Arginine

562/560

Asparagine

562/561

Aspartic acid

562/571

Cysteine

562/557

Glutaminic acid

562/573

Glycine

562/575 Histidine

548/344

Isoleucine

562/575

Leucine

562/575

Lysine

562/562

Methionine

562/559

Phenylalanine 562/445

Proline

548/535

Serine

562/567

Theronine

562/570

Tryptophan

548/496

Tyrosine

562/444

Rare amino acids from proteins Desmosine

546/335

5 Hydroxylsine

562/564

5-Hydroxyproline

548/532

Isodesmosine

546/335

3-Methythistidine

548/335

E-N-Methyllysine

562/561

Nonprotein Amino Acids

B-Alanine

562/576

V-Aminobutyric acid

562/553

Canavanine

562/560

Citrulline

562/560

B-Cyanvalanine

260/465 Djenkolic acid

562/557

Homocysteine

562/556

Homoserine

562/567

Ornithine

562/561

Valine

526/575

(8) Note. Peptide and Protein Structure. The nature, i.e., identity, of the constituent amino acids and their sequence is referred to as the primary structure. A given primary structure will have a definite three dimensional structure which is called the secondary structure (usually helical coiling). The secondary structure of a large peptide or protein is wrapped about and interwoven to develop the overall three dimensional structure of the molecule. This arrangement of the secondary structure is referred to as the tertiary structure and determines the alosteric properties of many proteins.

SEE OR SEARCH CLASS

106, Compositions: Coating or Plastic, for protein containing coating or plastic compositions, particularly

4, 24, 124+, 645+, and indented subclasses.

117, Single-Crystal, Oriented-Crystal, and Epitaxy Growth Processes; Non-Coating Apparatus Therefor, for processes for growing therein-defined single-crystal of all types of materials, including inorganic or organic.

424, Drug, Bio-Affecting and Body Treating Compositions has the following subclasses for proteins or proteinaceous material 1.11+, for radionuclide or intended radionuclide containing; 65+, 418, 456, 460, 477+, 491+, 499, for a protein or peptide containing compositions which functions as an antiperspirant or deodorant; for a composition containing a lymphokine; 130.1+ for a composition containing an immunoglobulin, an antiserum, an antibody, or an antibody fragment; 184.1+ for a composition containing an antigen, an epitope, or another immunospecific immunoeffector that may be proteinaceous; 278.1+ for a composition containing a nonspecific immunoeffector that may be proteinaceous; 94.1+, for composition containing proteins identified as enzymes; 520+, for compositions many of which are considered to be proteinaceous; an animal extract of undetermined constitution; 115+ for compositions which may be proteins or peptides identified by elemental analysis.

426, Food or Edible Material: Processes, Compositions, and Products, appropriate subclasses, especially

63, 92, 105 for edible protein compositions or products and related process involving the same.

428, Stock Material or Miscellaneous Articles, for a nonstructural stock material product in the form of a composite web or sheet including a layer comprising protein, and other appropriately titled subclasses (i.e.,

435, and 458).

430, Radiation Imagery Chemistry: Process, Composition, or Product Thereof,

59.6, 537, 539, 629, 640, 642, and 643 for compositions containing proteins used in forming an image.

435, Chemistry: Molecular Biology and Microbiology, 68.1+, for the microbial or enzymatic synthesis of proteins and peptides; subclasses 183+ for the production of enzymes; and subclasses 174+ for the formation of immobilized enzymes and subclasses 269 and 272+ for the liberation or purification of proteins by means of microorganism or enzyme, particularly subclass 273 for the purification of collagen or gelatin.

436, Chemistry: Analytical and Immunological Testing,

15, for a protein containing composition used as a standard or control; 16, for a blood standard; 66, for test for blood clotting factor tests; 86+, for tests for protein or peptides including sequencing methods and subclass 501 for a complement binding assays and protein binding assays and subclasses 506-548 for tests using antigen antibody interactions in a chemical test particularly subclasses 543-548 which collect methods of modifying antigens and antibodies as part of a testing procedure.

514, Drug, Bio-Affecting and Body Treating Compositions,

1, 21 and Cross-Reference Art Collections 800-809 which provide for compositions having a 424 utility containing a peptide or protein as an organic active ingredient.

524, Synthetic Resins or Natural Rubbers,

9+, for plant or plant derived cellular material; subclasses 17+ for proteins or biologically active polypeptide or for a process in which the protein or polypeptide is physically mixed with a preformed resin and subclasses 70+ for a process of adding a protein or biologically active polypeptide to resin forming ingredients during reaction of the resin formers and the protein or polypeptide is nonreactive; and subclasses 21+ for animal derived proteins such as blood, particularly subclasses 22+ for Gelatin and subclasses 25+ for Casein, for a process in which the protein is physically mixed with a preformed resin.

525, Synthetic Resins or Natural Rubbers,

54.1, for the chemical reaction of a peptide or protein with a preformed resin and subclass 54.11 for processes of stepwise assembly of a polypeptide on a preformed polymer, i.e., solid phase synthesis when there is no claimed cleavage of the synthesized polypeptide and subclass 54.24 for the chemical reaction of a flour or meal with a preformed resin.

526, Synthetic Resin or Natural Rubbers,

238.1, for the formation of a synthetic resin from a protein or biologically active polypeptide where the protein or polypeptide as well as all other reactants are ethylenically unsaturated. 527, Synthetic Resins or Natural Rubbers,

100+, and 200+ for the formation of a synthetic resin by simultaneous chemical reaction of a protein cellular material (e.g., hair, horn, leather) or a protein or biologically active polypeptide and resin forming ingredient.

528, Synthetic Resins or Natural Rubbers, particularly

328, for a polymer of amino acids and methods of making such a polyamino acid.

930, Peptide or Protein Sequence,

10+, for peptide or protein sequences of four or more amino acids.