US PATENT SUBCLASS 530 / 335
.~.~ Protecting or removing protective groups, e.g., carboxyl group protection, etc.

Current as of: June, 1999
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530 /   HD   CHEMISTRY: NATURAL RESINS OR DERIVATIVES; PEPTIDES OR PROTEINS; LIGNINS OR REACTION PRODUCTS THEREOF

300  DF  PEPTIDES OF 3 TO 100 AMINO ACID RESIDUES {29}
333  DF  .~ Synthesis of peptides {4}
335.~.~ Protecting or removing protective groups, e.g., carboxyl group protection, etc. {2}
336  DF  .~.~.~> Of side chain or sulfur containing group
337  DF  .~.~.~> Of amino group

DEFINITION

Classification: 530/335

Protecting peotide functional groups or removing protective groups from peptides (e.g., protecting carboxy groups, etc.):

(under subclass 333) Processes wherein a peptide group, whose purpose is to protect a functional group in a peptide, is attached to or removed from a peptide.

(1) Note. Carboxyl group protective agents in general use include:

(a) alklyl esters that can be removed via saponification reactions (e.g., via NaOH); the tert-butyl group is a preferred carboxyl protecting group that can be removed via treatment with trifluoroacetic acid.

(b) benzyl ester, which can be reoved via: (1) catalytic hydrogenation; (2) treatment with Na in liquid amonia; or (3) saponification via NaOH

SEE OR SEARCH THIS CLASS, SUBCLASS:

334, for the protection of a functional group in a peptide, or for the removal of a protective group from a peptide, during a solid phase synthesis.