US PATENT SUBCLASS 435 / 443
.~.~ By use of intercalating agent (e.g., acridine orange, etc.)

Current as of: June, 1999
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435 /   HD   CHEMISTRY: MOLECULAR BIOLOGY AND MICROBIOLOGY

440  DF  PROCESS OF MUTATION, CELL FUSION, OR GENETIC MODIFICATION {6}
441  DF  .~ Mutation employing a chemical mutagenic agent {4}
443.~.~ By use of intercalating agent (e.g., acridine orange, etc.)

DEFINITION

Classification: 435/443

By use of intercalating agent (e.g., acridine orange, etc.):

(under subclass 441) Processes involving a compound which intercalates between bases in a DNA molecule.

(1) Note. Examples of intercalating agents include acridine orange, 2-nitro-7-methoxynaphtho-[2,1-b]-furan, and acriflavin.

(2) Note. The mode of action of the intercalating agent is that it inserts between two base pairs. The consequence is that when the DNA with intercalating agent is replicated,

additional bases appear in its sequence and, though less common, deletion of a base may also occur.