US PATENT SUBCLASS 424 / 145.1
.~.~ Binds hormone or other secreted growth regulatory factor, differentiation factor, or intercellular mediator (e.g., cytokine, etc.); or binds serum protein, plasma protein (e.g., tPA, etc.), or fibrin

Current as of: June, 1999
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424 /   HD   DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS

130.1  DF  IMMUNOGLOBULIN, ANTISERUM, ANTIBODY, OR ANTIBODY FRAGMENT, EXCEPT CONJUGATE OR COMPLEX OF THE SAME WITH NONIMMUNOGLOBULIN MATERIAL {18}
141.1  DF  .~ Monoclonal antibody or fragment thereof (i.e., produced by any cloning technology) {8}
145.1.~.~ Binds hormone or other secreted growth regulatory factor, differentiation factor, or intercellular mediator (e.g., cytokine, etc.); or binds serum protein, plasma protein (e.g., tPA, etc.), or fibrin

DEFINITION

Classification: 424/145.1

Binds hormone or other secreted growth regulatory factor, differentiation factor, or intercellular mediator (e.g., cytokine, etc.); or binds serum protein, plasma protein (e.g., tPA, etc.), or fibrin:

(under subclass 141.1) Subject matter involving a monoclonal antibody or antigen-binding fragment thereof whose antigen-binding site(s) will combine with a hormone or with any other secreted growth regulatory factor, differentiation factor, or intercellular mediator; or involving a monoclonal antibody or antigen-binding fragment thereof whose antigen-binding site(s) will combine with a serum protein, a plasma protein, or with fibrin.

(1) Note. The term "growth regulatory factor" is meant to encompass any secretory factor that is growth-stimulatory or growth-inhibitory (e.g., that will stimulate or inhibit clonal expansion of cells).

(2) Note. The term "differentiation factor" is meant to encompass any secretory factor that causes cells to progress from a relatively undifferentiated state to a more differentiated state, wherein said progression may include clonal expansion.

(3) Note. The term "intercellular mediator" is meant to encompass any secretory factor that affects cellular functions such as chemotaxis, etc.

(4) Note. Patents under the class definition with disclosures to monoclonal antibodies or fragments thereof that bind proteins, including enzymes, that are members of plasma "activation systems"--including the clotting system, the fibrinolytic system, the bradykinin system, and the complement system--are proper for this subclass.

(5) Note. Patents under the class definition with disclosures to non-anti-idiotypic monoclonal antibodies or fragments thereof that bind immunoglobulins are proper for this subclass, unless the monoclonal antibodies specifically bind hematopoietic-cell-bound immunoglobulins, in which case, they are proper for subclass 153.1.

SEE OR SEARCH CLASS

530, Chemistry: Natural Resins or Derivative, 380+, for examples of plasma and serum proteins.