US PATENT SUBCLASS 424 / 136.1
.~.~ Bispecific or bifunctional, or multispecific or multifunctional, antibody or fragment thereof

Current as of: June, 1999
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424 /   HD   DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS

130.1  DF  IMMUNOGLOBULIN, ANTISERUM, ANTIBODY, OR ANTIBODY FRAGMENT, EXCEPT CONJUGATE OR COMPLEX OF THE SAME WITH NONIMMUNOGLOBULIN MATERIAL {18}
133.1  DF  .~ Structurally-modified antibody, immunoglobulin, or fragment thereof (e.g., chimeric, humanized, CDR-grafted, mutated, etc.) {3}
136.1.~.~ Bispecific or bifunctional, or multispecific or multifunctional, antibody or fragment thereof

DEFINITION

Classification: 424/136.1

Bispecific or bifunctional, or multispecific or multifunctional, antibody or fragment thereof:

(under subclass 133.1) Subject matter involving an antibody or fragment thereof that is bispecific or bifunctional or multispecific or multifunctional.

(1) Note. An unmodified antibody has one bivalent antigenic binding specificity. A bispecific or bifunctional antibody has two nonidentical antigenic binding specificities, each of which may be monovalent, bivalent, or multivalent. A multispecific or multifunctional antibody has more than two

nonidentical antigenic binding specificities, each of which may be monovalent, bivalent, or multivalent.

(2) Note. Bispecific or bifunctional antibodies, or multispecific or multifunctional antibodies, may be made by various techniques, ranging from chemical crosslinking of antibodies or fragments thereof having different binding specificities, to the preparation of quadromas, or fused hybridomas, that secrete bispecific antibodies, to the molecular cloning of the relevant genes, possibly followed by chemical coupling of the products produced thereby.