US PATENT SUBCLASS 424 / 135.1
.~.~ Single chain antibody

Current as of: June, 1999
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424 /   HD   DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS

130.1  DF  IMMUNOGLOBULIN, ANTISERUM, ANTIBODY, OR ANTIBODY FRAGMENT, EXCEPT CONJUGATE OR COMPLEX OF THE SAME WITH NONIMMUNOGLOBULIN MATERIAL {18}
133.1  DF  .~ Structurally-modified antibody, immunoglobulin, or fragment thereof (e.g., chimeric, humanized, CDR-grafted, mutated, etc.) {3}
135.1.~.~ Single chain antibody

DEFINITION

Classification: 424/135.1

Single chain antibody:

(under subclass 133.1) Subject matter wherein the material is a single polypeptide chain that has antigen-binding capability.

(1) Note. Single chain antibodies may possess amino acid sequences homologous to the complementarity determining, or hypervariable, regions found in native antibodies, as well as their flanking framework regions.

(2) Note. Single chain antibodies may be chimeric (e.g., having amino acid sequences homologous to complementarity determining regions and flanking framework regions, respectively, that are derived from different species).

(3) Note. Single chain antibodies may possess an amino acid sequence homologous to the variable region of an immunoglobulin light chain and an amino acid sequence homologous to the variable region of an immunoglobulin heavy chain, which amino acid sequences are joined by a polypeptide linker via chemical coupling or via expression of a gene fusion.

(4) Note. Single chain antibodies may be termed single chain binding proteins.