.~ Linear peptide or protein containing a nonpeptide or abnormal peptide link (See note 5) {1}
31
.~.~ Retro-inverted
DEFINITION
Classification: 930/31
Retro-inverted:
Subject matter under cross-reference art collection 30 containing a peptide or protein which is retro-inverted.
(1) Note. Retro-inversion is a way of protecting peptide substances against proteolysis. It entails retro-inverting those peptide bonds most susceptible to enzymatic hydrolysis by inverting the direction of the peptide bonds. The "retro-inverso peptides" are structural isomers of the reference peptides and as such preserve their biological activity while being more resistant to enzymatic hydrolysis.
