US PATENT SUBCLASS 424 / 235.1
.~.~ Transposon mutant or deletion mutant bacterium (e.g., produced by transposon mutagenesis, etc.)

Current as of: June, 1999
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424 /   HD   DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS

184.1  DF  ANTIGEN, EPITOPE, OR OTHER IMMUNOSPECIFIC IMMUNOEFFECTOR (E.G., IMMUNOSPECIFIC VACCINE, IMMUNOSPECIFIC STIMULATOR OF CELL-MEDIATED IMMUNITY, IMMUNOSPECIFIC TOLEROGEN, IMMUNOSPECIFIC IMMUNOSUPPRESSOR, ETC.) {15}
234.1  DF  .~ Bacterium or component thereof or substance produced by said bacterium (e.g., Legionella, Borrelia, Anaplasma, Shigella, etc.) {23}
235.1.~.~ Transposon mutant or deletion mutant bacterium (e.g., produced by transposon mutagenesis, etc.)

DEFINITION

Classification: 424/235.1

Transposon mutant or deletion mutant bacterium (e.g., produced by transposon mutagenesis, etc.):

(under subclass 234.1) Subject matter involving a transposon mutant or a deletion mutant bacterium.

(1) Note. For the purpose of this subclass, a transposon mutant bacterium is a bacterium whose genome has been modified by the introduction of a transposon--a sequence of double-stranded DNA that is able to replicate and insert a copy of itself at another site--which transposon has inserted a copy of itself at a site in the genome such that a gene of a particular biosynthetic pathway has been inactivated, so as to produce a desired characteristic in the mutant bacterium, such as attentuated virulence.

(2) Note. For the purpose of this subclass, a deletion mutant bacterium is one whose genome has been altered by recombinant DNA techniques so as to produce a variant that is lacking one more specifically-identified active gene products, and thus has certain desired characteristics, such as non-reverting attentuated virulence.

(3) Note. The mutant bacteria disclosed herein may be useful in attenuated live vaccines.

SEE OR SEARCH THIS CLASS, SUBCLASS:

200.1, for a recombinant or stably-transformed bacterium encoding one or more heterologous proteins or fragments thereof, which recombinant or stably-transformed bacteria may also be a transposon mutant or a deletion mutant.