US PATENT SUBCLASS 424 / 1.41
.~ Attached to lymphokine, cytokine, or other secreted growth regulatory factor, differentiation factor, or intercellular mediator specific for a hematopoietic cell (e.g., interferon, interleukin, macrophage factor, colony stimulating factor, erythropoietin); derivative thereof

Current as of: June, 1999
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424 /   HD   DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS

1.11  DF  RADIONUCLIDE OR INTENDED RADIONUCLIDE CONTAINING; ADJUVANT OR CARRIER COMPOSITIONS; INTERMEDIATE OR PREPARATORY COMPOSITIONS {11}
1.41.~ Attached to lymphokine, cytokine, or other secreted growth regulatory factor, differentiation factor, or intercellular mediator specific for a hematopoietic cell (e.g., interferon, interleukin, macrophage factor, colony stimulating factor, erythropoietin); derivative thereof

DEFINITION

Classification: 424/1.41

Attached to lymphokine, cytokine, or other secreted growth regulatory factor, differentiation factor, or intercellular mediator specific for a hematopoietic cell (e.g., interferon, interleukin, macrophage factor, colony stimulating factor, erythropoietin); derivative thereof:

(under subclass 1.11) Subject matter in which the radionuclide or intended radionuclide is attached (bonded, chelated, complexed) to a lymphokine, cytokine, or other secreted growth regulatory factor, differentiation factor, or intercellular mediator specific for any type of hematopoietic cell; and the derivatives thereof.

(1) Note. The term "growth regulatory factor" is meant to encompass any secretory factor that is growth-stimulatory or growth-inhibitory (i.e., that will stimulate or inhibit cluneal expansion of cells).

(2) Note. The term "differentiation factor" is meant to encompass any secretory factor that causes cells to progress from a relatively undifferentiated state to a more differentiated state, wherein said progression may include cluneal expansion.

(3) Note. The term "intercellular mediator" is meant to encompass any secretory factor that affects cellular functions such as chemotaxis, etc.

(4) Note. Included here are: interferon (IF), interleukin, monokines, macrophage factors, lymphokines, migration inhibitory factor (MIF), lymphotoxin (LT), leukocyte migration inhibitory factor (CIF), eosinophil chemotactic factor-precursor substance (ECFp), eosinophil stimulation promoter, eosinophil chemotactic factor, monocyte tissue factor, mitogenic factor (MF), lymphocyte activity-factor (LAF), colony stimulating factor (CSF), skin reactive factor (SRF), macrophage cytotoxicity factor (MCF), leukocyte inhibition factor (LIF), vascular permeability factor (VPF), T cell growth factor (TCGF), B cell growth factor (BCGF), erythroid burst promoter, genetically related macrophage factor (GRF), fibroblast activating factor (FAF), tumor necrosis factor (TNF), and macrophage activating factor (MAF).

(5) Note. Hematopoietic cells are considered to be bone marrow stem cells and cells derived from bone marrow stem cells, including cells at any stage of differentiation from progenitor cells to mature erythrocytes, granulocytes, lymphocytes, etc., both normal and neoplastic.